The biggest margin of victory in IPL history (by runs) was achieved by Mumbai Indians (MI) against Delhi Daredevils (now Delhi Capitals) on May 6, 2017. MI posted 213 runs, and Delhi Daredevils were bowled out for 66, resulting in a 146-run victor.
Other large margins of victory include:
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Royal Challengers Bangalore (RCB) vs. Gujarat Lions (144 runs, May 14, 2016)
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Kolkata Knight Riders (KKR) vs. Royal Challengers Bangalore (140 runs, April 18, 2008)
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RCB vs. Kings XI Punjab (138 runs, May 6, 2015)